Genetic determinants of the efficiency of climatotherapy in patients with chronic heart failure.

Authors: Kovlen DV (1) , Tishakov AY (1) , Glotov OS (1) , Moskalenko MV (1) , Demin GS (1) , Bitsadze AN (1) , Chernyshev AV (1) , Bratova NI (1) , Ivashchenko TE (1) , Obrezan AG (1) , Ponomarenko GN (1)
Affiliations:
(1) Department of Balneology and Physiotherapy, S. M. Kirov Military Medical Academy
Source: Bull Exp Biol Med. 2007 Jan;143(1):26-31.
DOI: 10.1007/s10517-007-0008-z Publication date: 2007 Jan E-Publication date: Not specified Availability: abstract Copyright: © 2007, Springer Science+Business Media, Inc.
Language: English Countries: Not specified Location: Not specified Correspondence address: Kovlen DV : denis.kovlen@mail.ru

Keywords

Article abstract

We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca(2+)-ATPase, phospholamban, beta1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca(2+)-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the beta1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca(2+)-ATPase and beta1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.

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