Circulating opioid peptides during water immersion in normal man.

Authors: Coruzzi P (1) , Ravanetti C (1) , Musiari L (1) , Biggi A (1) , Vescovi PP (2) , Novarini A (1)

Affiliations:

(1) Istituto di Semeiotica Medica, University of Parma (2) Istituto di Clinica Medica Generale e Terapia Medica, University of Parma

Source: Clin Sci (Lond). 1988 Feb;74(2):133-6.

Language: English Countries: Not specified Location: Not specified Correspondence address: Dr Paolo Coruzzi, Istituto di Semeiotica Medica, Via Gramsci, 14,I-43100 Parma, Italy

Keywords

Article abstract

1. This study was designed to evaluate variations in plasma beta-endorphin, methionine-enkephalin, adrenocorticotropic hormone and serum prolactin in healthy volunteers during head-out water immersion.

2. Water immersion induced an increase in methionine-enkephalin plasma levels, which was associated with a significant fall in mean arterial pressure and heart rate.

3. Conversely, a suppression of plasma beta-endorphin, adrenocorticotropic hormone and serum prolactin was detected during water immersion.

4. We suggest that a dopaminergic inhibitory control mechanism may be involved in regulating circulating levels of beta-endorphin, adrenocorticotropic hormone and prolactin in normal subjects undergoing extracellular fluid volume expansion produced by water immersion.

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